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Mudge, E. M.; Lewis, N.; Miles, C. O.; McCarron, P.; Uhlig, S.; Kryuchkov, F.; Gwinn, J. K.; Robertson, A.(November, 2023). Identification of Caribbean ciguatoxins from benthic dinoflagellates: Advances in knowledge on toxin chemistry and analysis. Harmful Algae UNESCO IOC, 73, 10. 

Optically active defects in 2D materials, such as hexagonal boron nitride (hBN) and transition metal dichalcogenides (TMDs), are an attractive class of single-photon emitters with high brightness, room-temperature operation, site-specific engineering of emitter arrays, and tunability with external strain and electric fields. In this work, we demonstrate a novel approach to precisely align and embed hBN and TMDs within background-free silicon nitride microring resonators. Through the Purcell effect, high-purity hBN emitters exhibit a cavity-enhanced spectral coupling efficiency up to 46% at room temperature, which exceeds the theoretical limit for cavity-free waveguide-emitter coupling and previous demonstrations by nearly an order-of-magnitude. The devices are fabricated with a CMOS-compatible process and exhibit no degradation of the 2D material optical properties, robustness to thermal annealing, and 100 nm positioning accuracy of quantum emitters within single-mode waveguides, opening a path for scalable quantum photonic chips with on-demand single-photon sources. 

Heparin is an essential anticoagulant used for treating and preventing thrombosis. However, the complexity of heparin has hindered the development of a recombinant source, making its supply dependent on a vulnerable animal population. In nature, heparin is produced exclusively in mast cells, which are not suitable for commercial production, but mastocytoma cells are readily grown in culture and make heparan sulfate, a closely related glycosaminoglycan that lacks anticoagulant activity. Using gene expression profiling of mast cells as a guide, a multiplex genome engineering strategy was devised to produce heparan sulfate with high anticoagulant potency and to eliminate contaminating chondroitin sulfate from mastocytoma cells. The heparan sulfate purified from engineered cells grown in chemically defined medium has anticoagulant potency that exceeds porcinederived heparin and confers anticoagulant activity to the blood of healthy mice. This work demonstrates the feasibility of producing recombinant heparin from mammalian cell culture as an alternative to animal sources. 

A<sc>bstract</sc> Inclusive and differential cross sections for Higgs boson production in proton-proton collisions at a centre-of-mass energy of 13.6 TeV are measured using data collected with the CMS detector at the LHC in 2022, corresponding to an integrated luminosity of 34.7 fb⁻¹. Events with the diphoton final state are selected, and the measured inclusive fiducial cross section is$${\sigma }_{\text{fid}}={74}\pm {11}{\left({\text{stat}}\right)}_{-4}^{+5}\left({\text{syst}}\right)$$fb, in agreement with the standard model prediction of 67.8 ± 3.8 fb. Differential cross sections are measured as functions of several observables: the Higgs boson transverse momentum and rapidity, the number of associated jets, and the transverse momentum of the leading jet in the event. Within the uncertainties, the differential cross sections agree with the standard model predictions. 

A measurement is presented of the cross section in proton-proton collisions for the production of two $W$bosons and one $Z$boson. It is based on data recorded by the CMS experiment at the CERN LHC at center-of-mass energies $\sqrt{s}=13$and 13.6 TeV, corresponding to an integrated luminosity of $200{\mathrm{fb}}^{-1}$. Events with four charged leptons (electrons or muons) in the final state are selected. Both nonresonant $WWZ$production and $ZH$production, with the Higgs boson decaying into two $W$bosons, are reported. For the first time, the two processes are measured separately in a simultaneous fit. Combining the two modes, signal strengths relative to the standard model (SM) predictions of ${0.75}_{-0.29}^{+0.34}$and ${1.74}_{-0.60}^{+0.71}$are measured for $\sqrt{s}=13$and 13.6 TeV, respectively. The observed (expected) significance for the triboson signal is 3.8 (2.5) standard deviations for $\sqrt{s}=13.6\mathrm{TeV}$, thus providing the first evidence for triboson production at this center-of-mass energy. Combining the two modes and the two center-of-mass energies, the inclusive signal strength relative to the SM prediction is measured to be ${1.03}_{-0.28}^{+0.31}$, with an observed (expected) significance of 4.5 (5.0) standard deviations.